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Vitamins

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By: Sean Moloughney

Editor, Nutraceuticals World

Indication: Pre-eclampsia

Source: American Journal of Epidemiology, September 2006;164(5):470-477.

Research:
The objective of this study was to assess the independent effect of regular periconceptional (before pregnancy) multivitamin use on the risk of pre-eclampsia. Over 1800 pregnant women enrolled in the Pregnancy Exposures and Pre-eclampsia Prevention Study (Pittsburgh, Pennsylvania, 1997–2001) at less than 16 weeks’ gestation and were asked whether they regularly used multivitamins or prenatal vitamins over the past six months. Women were classified as users or non-users.

Results:
After adjustment for race/ethnicity, marital status, parity, pre-pregnancy physical activity and income in a multiple logistic regression model, regular use of multivitamins was associated with a 45% reduction in pre-eclampsia risk compared with non-use. Pre-pregnancy overweight modified this effect. After confounder adjustment, lean multivitamin users had a 71% reduction in pre-eclampsia risk compared with lean non-users. In contrast, there was no relation between multivitamin use and pre-eclampsia among over-weight women.

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